I been having this virus problem ever since about noon this evening and I got it by simply opening a folder that i downloaded... I do not know why AVG or Malwarebytes didn't pick it up and i have no clue what it is, but rather this its really starting annoying the heck outta me. It won't even let me use Internet Explorer and everytime i try to access my files a annoying error pop up message tells me to download a anti-spyware program, photos below, some body please help me!!

When I try opening my files

-The Pop up error message!- Fake

I say
NO but it takes me to this....
Somebody please help.... alot of thanks in advance