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Thanks, AdvancedSetup. Dug deeper and figured it out. The writing of the RunOnce key was being blocked by a new version/rule set of McAfee VirusScan. By adding MBAM-SETUP.TMP to the particular rule's exclusions list within McAfee, the problem was resolved. Interestingly, I also had to add MBAM.EXE to another rule's exclusion list so that Internet updates would be allowed. Greg

Hello, Haven't run into this before; received this message when trying to install version 1.32: Error writing to registry key: HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\RunOnce RegSetValueEx failed; code 5. Access is denied. Click Retry to try again, Ignore to proceed anyway, or Abort to cancel installation. I am running Windows XP SP3, IE7 with latest updates. I am logged in with an account which is a Local Administrator (in fact a Domain Administrator). I've tried uninstalling/reinstalling. The installation will finish if I Ignore, but it won't let me connect to get updates. I ran a scan and it is coming up clean. Any ideas? Thanks, Greg